Antibiotic Resistance Evolution Simulator (ARES)
ARES is a simulator of the transfer dynamics of antibiotic resistance in bacterial communities. It is a computer simulator completely developed under the paradigm of membrane computing.
The simulator was developed by a multidisciplinary team led by Dr. Fernando Baquero (IRYCIS) and with the participation of the Universitat Politècnica de València, FISABIO, the Universidad de Valencia and the biotech company Biotechvana led by its CEO Dr. Carlos Llorens.
ARES allows the design of customized scenarios where different biological aspects of the spread of resistances, as well as social aspects of human hosts, such as their mobility and transfer rates, can be parameterized.
ARES has given rise to various scientific publications:
1. Simulating the Influence of Conjugative-Plasmid Kinetic Values on the Multilevel Dynamics of Antimicrobial Resistance in a Membrane Computing Model. Marcelino Campos, Álvaro San Millán, José M. Sempere, Val F. Lanza, Teresa M. Coque, Carlos Llorens, Fernando Baquero. Antimicrobial Agents and Chemotherapy August 2020, 64(8) e00593-20
DOI:10.1128/AAC.00593-20
2. Simulating Multilevel Dynamics of Antimicrobial Resistance in a Membrane Computing Model. Marcelino Campos, Rafael Capilla, Fernando Naya, Ricardo Futami, Teresa Coque, Andrés Moya, Val Fernandez-Lanza, Rafael Cantón, José M. Sempere, Carlos Llorens, Fernando Baquero. mBio Jan 2019, 10 (1) e02460-18. 2019
DOI: 10.1128/mBio.02460-18
3. A membrane computing simulator of trans-hierarchical antibiotic resistance evolution dynamics in nested ecological compartments (ARES). Marcelino Campos, Carlos Llorens, José M. Sempere, Ricardo Futami, Irene Rodríguez, Purificación Carrasco, Rafael Capilla, Amparo Latorre, Teresa M. Coque, Andrés Moya and Fernando Baquero Biology Direct Vol. 10(41). 2015 DOI:10.1186/s13062-015-0070-9
The simulator was developed by a multidisciplinary team led by Dr. Fernando Baquero (IRYCIS) and with the participation of the Universitat Politècnica de València, FISABIO, the Universidad de Valencia and the biotech company Biotechvana led by its CEO Dr. Carlos Llorens.
ARES allows the design of customized scenarios where different biological aspects of the spread of resistances, as well as social aspects of human hosts, such as their mobility and transfer rates, can be parameterized.
ARES has given rise to various scientific publications:
1. Simulating the Influence of Conjugative-Plasmid Kinetic Values on the Multilevel Dynamics of Antimicrobial Resistance in a Membrane Computing Model. Marcelino Campos, Álvaro San Millán, José M. Sempere, Val F. Lanza, Teresa M. Coque, Carlos Llorens, Fernando Baquero. Antimicrobial Agents and Chemotherapy August 2020, 64(8) e00593-20
DOI:10.1128/AAC.00593-20
2. Simulating Multilevel Dynamics of Antimicrobial Resistance in a Membrane Computing Model. Marcelino Campos, Rafael Capilla, Fernando Naya, Ricardo Futami, Teresa Coque, Andrés Moya, Val Fernandez-Lanza, Rafael Cantón, José M. Sempere, Carlos Llorens, Fernando Baquero. mBio Jan 2019, 10 (1) e02460-18. 2019
DOI: 10.1128/mBio.02460-18
3. A membrane computing simulator of trans-hierarchical antibiotic resistance evolution dynamics in nested ecological compartments (ARES). Marcelino Campos, Carlos Llorens, José M. Sempere, Ricardo Futami, Irene Rodríguez, Purificación Carrasco, Rafael Capilla, Amparo Latorre, Teresa M. Coque, Andrés Moya and Fernando Baquero Biology Direct Vol. 10(41). 2015 DOI:10.1186/s13062-015-0070-9
